HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Fluoro-5-(3-(oxazol-5-yl)pyridin-2-yloxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Fluoro-5-(3-(oxazol-5-yl)pyridin-2-yloxy)benzoic acid | HCID 69166074 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Fluoro-5-(3-(oxazol-5-yl)pyridin-2-yloxy)benzoyl chloride | HCID 86623788 | — |
Reaction Steps
To 2-fluoro-5-(3-(oxazol-5-yl)pyridin-2-yloxy)benzoic acid (196 mg, 0.653 mmol) in CH2Cl2 (6.0 mL) was added oxalyl chloride (0.28 mL, 3.3 mmol) followed by DMF (2 drops). The mixture was stirred under nitrogen at rt for 15 hours. The reaction was concentrated to yield 2-fluoro-5-(3-(oxazol-5-yl)pyridin-2-yloxy)benzoyl chloride, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236823B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-a0f57f5366ef48e295ff7462b5a1aaee |
| Source note | uspto-grants-2012_08 |