反应详情

温度

70 °C

N[4-(Thiazol-2-ylsulfamoyl)-naphthalen-1-yl]acetamide (0.48 g, 1.38 mmol) was dissolved in 0.5 M NaOMe (20 ml) and heated at 70° C. for 16 h. After the solvents were evaporated, a 2:1 EtOH:H2O mixture (6 ml) and a few drops of AcOH were added. While stirring the mixture, a precipitate formed which was filtered and dried under vacuum to give 4-amino-naphthalene-1-sulfonic acid thiazol-2-ylamide (0.31 g, 73%). LC/MS (10-99% CH3CN), M/Z: M+1 obs=306.0; tR=2.04 min.

1. customAfter the solvents were evaporated
2. additiona 2:1 EtOH:H2O mixture (6 ml) and a few drops of AcOH were added
3. customa precipitate formed which
4. filtrationwas filtered
5. customdried under vacuum