p-(Trifluoromethoxy)benzaldehyde → 3-(4-(Trifluoromethoxy)benzyl)pyrrolidin-2-one

Participants

Reaction Steps

Following the procedure as described in Preparation 5, making variations as required to use 4-(trifluoromethoxy)benzaldehyde in place of 4-fluorobenzaldehyde to react with 1-(2,2,2-trifluoroacetyl)pyrrolidin-2-one, the title compound was obtained as a white solid in 53% yield: 1H NMR (300 MHz, CDCl3) δ 7.24-7.06 (m, 4H), 3.71-3.50 (m, 2H), 3.34-3.02 (m, 3H), 2.19-2.00 (m, 1H), 1.83-1.70 (m, 1H); MS (ES+) m/z 260.1 (M+1).

Provenance & Evidence