N-bromobutanimide → HCID 24799235, compound

HRID 883162Notes

Reaction equation

HRID 883162 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[S:15][C:14]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C:17]2=[O:22])=[N:13][C:12]=1[CH3:23])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:24]N1C(=O)CCC1=O>>[CH2:1]([NH:8][C:9]([C:11]1[S:15][C:14]([N:16]2[CH2:21][CH2:20][CH2:19][CH:18]([Br:24])[C:17]2=[O:22])=[N:13][C:12]=1[CH3:23])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 24799232N-benzyl-4-methyl-2-(2-oxopiperidin-1-yl)thiazole-5-carboxamide

Product 1

HCID 24799235HCID 24799235, compoundYield 56%

Procedure

Following the procedure as described in Example 4, making variations as required to use N-benzyl-4-methyl-2-(2-oxopiperidin-1-yl)thiazole-5-carboxamide in place of N-(4-fluorobenzyl)-4-methyl-2-(2-oxopyrrolidin-1-yl)thiazole-5-carboxamide to react with N-bromosuccinimide, the title compound was obtained as a yellow oil in 56% yield: MS (ES+) m/z 408.2 (M+1), 410.2 (M+1).

Sources & evidence

ORD record
ord-a2fe67ed54b14be2b423c01f3af33f45
Source dataset
uspto-grants-2012_08
Patent number
US08236835B2

Reaction notes

Loading…