HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 1-phenyl-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal | HCID 86639918 | — |
| Product | 1-phenyl-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25065460 | — |
Reaction Steps
116 mg (89%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal (80 mg, 0.276 mmol), 1-phenylpiperazine (0.041 mL, 0.276 mmol), DIPEA (0.072 mL, 0.414 mmol) and NaBH(OAc)3 (175 mg, 0.828 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236806B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-92ceb19a22524848a3dbc7b5dfd12410 |
| Source note | uspto-grants-2012_08 |