化工社化工社 化学情報印刷レポート · 研究参考用
Diisopropylethylamine → 4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Methyl-1-(m-tolyl)piperazine | HCID 2723804 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal | HCID 86639922 | — |
| 生成物 | 4-(3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-2-methyl-1-m-tolylpiperazine | HCID 68559535 | — |
反応手順
114 mg (85%) of target compound was obtained by using a method same as in Example 1 by using 3-(5-(4-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal (80 mg, 0.257 mmol), 2-methyl-1-m-tolylpiperazine (49 mg, 0.257 mmol), DIPEA (0.070 mL, 0.386 mmol) and NaBH(OAc)3 (163 mg, 0.771 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08236806B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-a6dae70d96f94fa398ad210581f511ea |
| 出典メモ | uspto-grants-2012_08 |