1-(2,4-Xylyl)piperazine → 1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	1-(2,4-Xylyl)piperazine	HCID 70544	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	Sodium triacetoxyborohydride	HCID 5049666	—
Reactant	3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propanal	HCID 86639923	—
Product	1-(3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine	HCID 25063990	—

Reaction Steps

139 mg (79%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-3-yl)propanal (100 mg, 0.365 mmol), 1-(2,4-dimethylphenyl)piperazine (69 mg, 0.365 mmol), DIPEA (0.1 mL, 0.548 mmol) and NaBH(OAc)3 (232 mg, 1.095 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08236806B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-a7281cfd34124930a683ad2176d39045
Source note	uspto-grants-2012_08