HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Xylyl)piperazine → 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal | HCID 86639924 | — |
| Product | 1-(3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine | HCID 25064225 | — |
Reaction Steps
96 mg (70%) of target compound was obtained by using a method same as in Example 1 by using 3-(5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)-propanal (80 mg, 0.272 mmol), 1-(2,4-dimethylphenyl)piperazine (52 mg, 0.272 mmol), DIPEA (0.071 mL, 0.408 mmol) and NaBH(OAc)3 (173 mg, 0.816 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236806B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-df033f3bf8be4df9b7f18d8acede4e88 |
| Source note | uspto-grants-2012_08 |