HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,3-Xylyl)piperazine → 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,3-Xylyl)piperazine | HCID 70541 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal | HCID 86639925 | — |
| Product | 1-(3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propyl)-4-(2,3-dimethylphenyl)piperazine | HCID 25064651 | — |
Reaction Steps
86 mg (96%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-(thiophene-2-yl)-1H-pyrazol-3-yl)propanal (50 mg, 0.191 mmol), 1-(2,3-dimethylphenyl)piperazine (36 mg, 0.191 mmol), DIPEA (0.050 mL, 0.287 mmol) and NaBH(OAc)3 (121 mg, 0.573 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236806B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-a7ad7256810443a28cc6d7cda6afb7ff |
| Source note | uspto-grants-2012_08 |