HCID 18738443, compound → HCID 18738434, compound

HRID 8834Notes

Reaction equation

HRID 8834 reaction equation
[N:1]1([S:7]([CH2:10][C@H:11]([CH3:22])[C:12]([O:14]CC2C=CC=CC=2)=[O:13])(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>[Pd]>[N:1]1([S:7]([CH2:10][C@H:11]([CH3:22])[C:12]([OH:14])=[O:13])(=[O:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 1

HCID 18738443HCID 18738443, compound

Product 1

HCID 18738434HCID 18738434, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A 100 mL Fisher/Porter vessel was charged with 1 g of benzyl 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionate 30 mL MeOH and a catalytic amount of 10% Pd—C. The reaction was hydrogenated at 50 psi for 3 hours. After filtration through Celite and concentration in vacuo of 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionic acid was isolated in quantitive yield.

Workup

  1. filtrationAfter filtration
  2. concentrationthrough Celite and concentration in vacuo of 3-(1-piperidinyl)sulfonyl-2(R)-methylpropionic acid
  3. customwas isolated in quantitive yield

Sources & evidence

ORD record
ord-8a2cbf7437764d01a0233567b8192452
Source dataset
uspto-grants-2006_08
Patent number
US07091219B2

Reaction notes

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