HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 2-methyl-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)-1-m-tolylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Methyl-1-(m-tolyl)piperazine | HCID 2723804 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propanal | HCID 86639931 | — |
| Product | 2-methyl-4-(3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propyl)-1-m-tolylpiperazine | HCID 68555206 | — |
Reaction Steps
68 mg (45%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-5-propyl-1H-pyrazol-3-yl)propanal (80 mg, 0.330 mmol), 2-methyl-1-m-tolylpiperazine (63 mg, 0.330 mmol), DIPEA (0.090 mL, 0.495 mmol) and NaBH(OAc)3 (210 mg, 0.990 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236806B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-daa7dde1ea29426684d4a98ae1c2e02a |
| Source note | uspto-grants-2012_08 |