Vanillin → 3-(4-Hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

Participants

Reaction Steps

Potassium hydroxide (20 g) in 100 g of diethylene glycol diethyl ether is heated to 120° C. while being stirred, and added to a mixture of 14 g of p-hydroxyacetophenone and 15 g of vanillin within 1 h. Upon completion of the addition stirring is continued for another 20 min., a hydrolysis is carried out and the pH is adjusted to 6-7. After phase separation, the solvent is removed and 25 g of 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propene-1-one is obtained. Yield: 93% of the theory.

Provenance & Evidence