反应详情

温度

120 °C

3-Isobutyl-2-thioxanthine (0.20 g, 0.89 mmol) and Lawesson's reagent (1.1 g, 2.7 mmol) were suspended in toluene (8 mL). This mixture was heated at 120° C. for 17 h. The reaction mixture was cooled and the solvent removed under reduced pressure. 10% Sodium hydroxide (20 mL) was added and the mixture stirred for 10 minutes. This solution was filtered to remove insoluble solids and the solid washed with 10% sodium hydroxide solution. The basic filtrate was treated with dilute acetic acid until pH 4 was reached. The resulting precipitate was collected by filtration and washed with water. Drying of the substance afforded the title compound (0.16 g, 73%).

1. temperatureThe reaction mixture was cooled
2. customthe solvent removed under reduced pressure
3. addition10% Sodium hydroxide (20 mL) was added
4. filtrationThis solution was filtered
5. customto remove insoluble solids
6. washthe solid washed with 10% sodium hydroxide solution
7. additionThe basic filtrate was treated with dilute acetic acid until pH 4
8. filtrationThe resulting precipitate was collected by filtration
9. washwashed with water
10. customDrying of the substance