反应详情

温度

85 °C

6-Amino-1-isobutyl-5-methylamino-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.11 g, 0.48 mmol) was dissolved in formic acid (1 mL) and heated at 85° C. for 1 h. The excess of formic acid was evaporated off under reduced pressure. 10% Sodium hydroxide solution (2 mL) was added and the solution was heated at 85° C. for 20 minutes. Water was added and the pH was adjusted to 4 with dilute acetic acid, upon which a white solid precipitated. The white solid was collected by filtration, washed with water and dried to yield the title compound (85 mg, 74%).

1. customThe excess of formic acid was evaporated off under reduced pressure
2. addition10% Sodium hydroxide solution (2 mL) was added
3. temperaturethe solution was heated at 85° C. for 20 minutes
4. additionWater was added
5. customprecipitated
6. filtrationThe white solid was collected by filtration
7. washwashed with water
8. customdried