Formic Acid → HCID 86601062, compound

HRID 883559Notes

Reaction equation

HRID 883559 reaction equation
[NH2:1][C:2]1[C:3](=[O:16])[NH:4][C:5](=[S:15])[N:6]([CH2:9][C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)[C:7]=1[NH2:8].[CH:17](O)=O>>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[CH2:9][N:6]1[C:7]2[N:8]=[CH:17][NH:1][C:2]=2[C:3](=[O:16])[NH:4][C:5]1=[S:15]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 86601063HCID 86601063, compound

Product 1

HCID 86601062HCID 86601062, compound

Conditions

Temperature
70 °C

Procedure

5,6-Diamino-1-(2-furyl-methyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.12 g, 0.51 mmol) in formic acid (0.5 mL) was stirred at ambient temperature for 0.5 h. The excess of formic acid was evaporated off and the resulting solid dissolved in 10% sodium hydroxide solution (3 mL). This solution was heated at 70° C. for 0.5 h. The reaction mixture was neutralized with 2M hydrochloric acid. The resulting precipitate was collected by filtration, washed with water, and dried. Yield: (0.047 g, 37%).

Workup

  1. customThe excess of formic acid was evaporated off
  2. dissolutionthe resulting solid dissolved in 10% sodium hydroxide solution (3 mL)
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-c2eb59c087f240a2a8825fcdf3203422
Source dataset
uspto-grants-2012_08
Patent number
US08236951B2

Reaction notes

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