HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl cyanoacetate → methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl cyanoacetate | HCID 7747 | — |
| Reactant | 5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione | HCID 2732752 | — |
| Product | methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate | HCID 67424559 | 77% |
Reaction Steps
Following the general method as outlined for Intermediate 1, starting from 5-(trifluoromethoxy)-isatin and methyl cyanoacetate, the title compound was isolated, after evaporation, as a dark purple solid in 77% yield. This was a 7.5:1 mixture of geometric isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236963B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-0b8386fe95eb4640b6b24d51e763efa5 |
| Source note | uspto-grants-2012_08 |