Potassium Cyanide → methyl cyano[3-cyano-2-oxo-5-(trifluoromethoxy)-2,3-dihydro-1H-indol-3-yl]acetate

Participants

Reaction Steps

Following the general method as outlined for Intermediate 5, starting from methyl (2Z)-cyano[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]acetate (intermediate 3) and potassium cyanide, the title compound was isolated, after evaporation, as a pale brown solid in 90% yield. This was a mixture of diastereomers.

Provenance & Evidence