Potassium Carbonate → HCID 58017139, compound

Participants

Reaction Steps

According to the general procedure as outlined above for the synthesis of intermediate 43, f 5-chloroisatin, compound VIII, (10.0 g, 55.07 mmol) was reacted with potassium carbonate (9.89 g, 5.03 mmol) and tert-butyl bromoacetate (8.95 ml, 60.58 mmol) in N,N-dimethylformamide (100 ml) to give the title compound (12.14 g, 75%) as orange solid (HPLC purity: 99%) after precipitation from water. MS (ESI−): 294.2

Provenance & Evidence