Hydrochloric Acid → HCID 58017122, compound

Participants

Reaction Steps

To a solution of ethyl-5-chloro-2-[(ethoxycarbonyl)oxy]-1H-indole-1-carboxylate, intermediate 49, (36.87 g, 118.28 mmol) in N,N-dimethylformamide (100 ml) 4-dimethylaminopyridine (14.45 g, 118.28 mmol) was added portionwise at 0-5° C. such that the internal temperature did not exceed 5° C. A thick suspension was obtained, which was repeatedly diluted with N,N-dimethylformamide (total volume: 350 ml) to ease up stirring. After two hours at 0-5° C. a solution of hydrogen chloride (fuming, 37%; 9.8 ml) in water (480 ml) was added at such a rate that the internal temperature could be kept below 15° C. The precipitate was filtered, washed with water at 0-5° C. (2×100 ml) and dried to yield the title compound (27.45 g, 70%) as off-white powder (HPLC purity: 94%). MS (ESI+): 312.2; MS (ESI−): 310.2

Provenance & Evidence