Dichloromethane → HCID 58017136, compound

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Reaction Steps

To a solution of diethyl-3-(2-tert-butoxy-2-oxoethyl)-5-chloro-2-oxoindoline-1,3-dicarboxylate, intermediate 51, (1.83 g, 4.30 mmol) in dichloromethane (30 ml) trifluoroacetic acid (3.18 ml, 42.97 mmol) was added at 0-5° C. Stirring was continued at 0-5° C. for 30 minutes and at ambient temperature overnight. Evaporation and drying under high vacuum gave the title compound (1.57 g, 99%) as colorless oil (HPLC purity: 85%). MS (ESI+): 370.2

Provenance & Evidence