2-Fluoroaniline → Tert-butyl 4-[(2-fluorophenyl)amino]piperidine-1-carboxylate

HRID 883771Notes

Reaction equation

HRID 883771 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[F:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH2:18].FC1C=C(NC2CCN(C(OC(C)(C)C)=O)CC2)C=CC=1>>[F:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH:18][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 95842-FluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 23137591tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

Product 1

HCID 43652152Tert-butyl 4-[(2-fluorophenyl)amino]piperidine-1-carboxylate

Procedure

The title compound was prepared from 1,1-dimethylethyl 4-oxo-1-piperidinecarboxylate and 2-fluoroaniline using a method similar to that described for D3 in Description 3.

Sources & evidence

ORD record
ord-63dfdaa46315401cbd33326ed44682a8
Source dataset
uspto-grants-2012_08
Patent number
US08236953B2

Reaction notes

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