3-[(Piperidin-4-yl)amino]benzonitrile → 2-(4-Piperidinylamino)benzonitrile

HRID 883774Notes

Reaction equation

HRID 883774 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][CH:10]1[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1)#[N:2].N1CCC(NC2C=C(C=CC=2)C#N)CC1>>[NH:13]1[CH2:12][CH2:11][CH:10]([NH:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:1]#[N:2])[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 252237973-[(Piperidin-4-yl)amino]benzonitrileHCID 576995121,1-Dimethylethyl 4-[(2-cyanophenyl)amino]-1-piperidinecarboxylate

Product 1

HCID 433458262-(4-Piperidinylamino)benzonitrile

Procedure

The title compound was prepared from 1,1-dimethylethyl 4-[(2-cyanophenyl)amino]-1-piperidinecarboxylate (D17) using a method similar to that described for D6 in Description 6.

Sources & evidence

ORD record
ord-04fea28d51254935942725eb41938f42
Source dataset
uspto-grants-2012_08
Patent number
US08236953B2

Reaction notes

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