3-[(Piperidin-4-yl)amino]benzonitrile → 2-(4-Piperidinylamino)benzamide

HRID 883776Notes

Reaction equation

HRID 883776 reaction equation
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1)=[O:3].N1CCC(NC2C=C(C=CC=2)C#N)CC1>>[NH:14]1[CH2:13][CH2:12][CH:11]([NH:10][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:2]([NH2:1])=[O:3])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 252237973-[(Piperidin-4-yl)amino]benzonitrileHCID 576995251,1-Dimethylethyl 4-{[2-(aminocarbonyl)phenyl]amino}-1-piperidinecarboxylate

Product 1

HCID 433458272-(4-Piperidinylamino)benzamide

Procedure

The title compound was prepared from 1,1-dimethylethyl 4-{[2-(aminocarbonyl)phenyl]amino}-1-piperidinecarboxylate (D19) using a method similar to that described for D6 in Description 6.

Sources & evidence

ORD record
ord-c7b0854141104b58b37754eedb6ff9c1
Source dataset
uspto-grants-2012_08
Patent number
US08236953B2

Reaction notes

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