4-Chloro-3-nitrophenol → HCID 57469887, compound

HRID 883837Notes

Reaction equation

HRID 883837 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Cl[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 691274-Chloro-3-nitrophenolHCID 697163-(Trifluoromethyl)benzyl chloride

Product 1

HCID 57469887HCID 57469887, compound

Procedure

A solution of 4-chloro-3-nitro-phenol was reacted with 1-chloromethyl-3-trifluoromethyl-benzene using the conditions described in Example 10C to provide 1-chloro-2-nitro-4-(3-trifluoromethyl-benzyloxy)-benzene which was treated sequentially using the procedures from Examples 10D and 10E to provide 4-[2-Amino-4-(3-trifluoromethyl-benzyloxy)-phenylsulfanyl]-phenol.

Sources & evidence

ORD record
ord-72414f4bc18942e3a7263dc1f0eaec54
Source dataset
uspto-grants-2012_08
Patent number
US08236950B2

Reaction notes

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