HCID 66808275, compound → HCID 67249384, compound

Participants

Reaction Steps

The product from Example 4a (88 mg, 0.40 mmol) was reacted with 4-[2-Amino-4-(3-trifluoromethyl-benzyloxy)-phenylsulfanyl]-phenol (151 mg, 0.40 mmol) in 5 mL of ethanol at 70° C. with stirring for 6 hours. After cooling to room temperature the product was isolated by suction filtration and was triturated with diethyl ether to give the title compound as a pale yellow solid (123 mg, 50%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 10.45 (s, 1H) 9.65 (s, 1H) 9.34 (s, 1H) 8.57 (s, 1H) 7.62-7.85 (m, 4H) 7.09-7.21 (m, 4H) 7.02 (dd, J=3.02 Hz, J=8.74 Hz, 1H) 6.74 (s, 1H) 6.65 (dd, J=2.19 Hz, J=8.74 Hz, 2H) 5.23 (s, 2H) 2.48 (s, 3H); (ESI+) m/z 575 (M+H−Cl)+; (ESI−) m/z 573 (m−H−Cl)−.

Provenance & Evidence