HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 883841Generated: October 27, 2026
Phosphorus oxychloride → 5-Chloro-2-methyl-1,8-naphthyridine
https://huagongshe.com/reaction/883841
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 7-methyl-8H-1,8-naphthyridin-4-one | HCID 178422956 | — |
| Product | 5-Chloro-2-methyl-1,8-naphthyridine | HCID 12266372 | 90% |
Reaction Steps
A mixture of the product from Example 7c (320 mg, 2.0 mmol) in 6 mL of POCl3 was heated at 50° C. with stirring for 6 h. Cooled to room temperature and quenched by pouring into ice. Adjusted to pH 10 with NH4OH and extracted with CH2Cl2. Dried over Na2SO4′ filtered and concentrated under vacuum giving the title compound as a tan solid (322 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08236950B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-9d42504de3524b9bb3362f9f233b5f3b |
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| Source note | uspto-grants-2012_08 |
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