HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 883847Generated: October 25, 2026
Diethyl (ethoxymethylene)malonate → Diethyl 2-((6-ethylpyridin-2-ylamino)methylene)malonate
https://huagongshe.com/reaction/883847
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 6-Ethylpyridin-2-amine | HCID 89021 | — |
| Product | Diethyl 2-((6-ethylpyridin-2-ylamino)methylene)malonate | HCID 12354398 | — |
Reaction Steps
The crude product from Example 8b was combined with 2-ethoxymethylene-malonic acid diethyl ester (6.6 mL, 0.032 mol) and the mixture heated under a N2 atmosphere in an oil bath at 100° C. for 2 h. Purified by flash chromatography on silica gel eluting with EtOAc/hexane giving the title compound (7.16 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08236950B2 |
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| Source dataset | uspto-grants-2012_08 |
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| ORD ID | ord-eb849b1d0bbe4df2b73112607cc62a02 |
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| Source note | uspto-grants-2012_08 |
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