N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine → 4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol

Participants

Role	Name	HCID	Charge
Reactant	N'-(3-Cyano-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808319	—
Reactant	4-[2-Amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol	HCID 66808677	—
Reactant	3-Amino-4-(4-hydroxy-phenylsulfanyl)-phenol	HCID 67040301	—
Product	4-(4-Hydroxy-phenylsulfanyl)-3-(pyrido[2,3-d]pyrimidin-4-ylamino)-phenol	HCID 67040784	35.4%

Reaction Steps

The product of Example 16B (380 mg, 1.63 mmol) was reacted with the product of Example 15A (284 mg, 1.63 mmol) using the procedure of Example 15E substituting the product of Example 16B for the product of Example 15D to provide a solid which was triturated with methanol to provide the title compound (209 mg, 35%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08236950B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-7d933d83cff84ce6b090c50c1425ffb0
Source note	uspto-grants-2012_08