5-Chloro-2-methyl-1,8-naphthyridine → HCID 24897972, compound

Participants

Reaction Steps

The product from Example 7d (277 mg, 0.156 mmol) was reacted with the product from Example 9c (361 mg, 0.156 mmol) for 5 h by the procedure in Example 7g giving the title compound after purification of the crude product by HPLC with TFA as the trifluoroacetic acid salt (231 mg, 30%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 2.33 (s, 3 H) 2.77 (s, 3 H) 6.29 (d, J=6.99 Hz, 1 H) 6.73 (d, J=8.82 Hz, 2 H) 7.01 (d, J=7.72 Hz, 1 H) 7.19 (d, J=8.46 Hz, 2 H) 7.24 (s, 1 H) 7.27 (s, 1 H) 7.81 (d, J=8.82 Hz, 1 H) 8.44 (d, J=6.99 Hz, 1 H) 9.01 (d, J=8.82 Hz, 1 H) 9.91 (s, 1 H) 11.03 (s, 1 H) 14.38 (br. s, 1 H); MS (ESI+) m/z 374 (M+H)+.

Provenance & Evidence