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Phosphorus oxychloride → Ethyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 5373687 | — |
| 生成物 | Ethyl 4-chloro-7-methyl-1,8-naphthyridine-3-carboxylate | HCID 10562672 | 57% |
反応手順
The product from Example 7b (1.0 g, 4.30 mmol) was reacted with 12 mL of POCl3 for 4 h following the procedure from Example 7d giving the title compound as a brownish-pink solid (619 mg, 57%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08236950B2 |
| 出典データセット | uspto-grants-2012_08 |
| ORD ID | ord-f7d5db8c756f4e4f9f8aa34de6741ab5 |
| 出典メモ | uspto-grants-2012_08 |