HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichloro-1,8-naphthyridine → N-{4-[2-(7-Chloro-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichloro-1,8-naphthyridine | HCID 15588316 | — |
| Reactant | N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide | HCID 43168935 | — |
| Product | N-{4-[2-(7-Chloro-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenyl}-acetamide | HCID 86615485 | 48% |
Reaction Steps
The product from Example 21d (200 mg, 1.0 mmol) and the product from Example 22b (215 mg, 1.0 mmol) were reacted following the procedure from Example 7g giving a crude solid that was purified by HPLC with TFA to give the title compound 200 mg, 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236950B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-5f8c4c0dc78545639c106a8c021fe89b |
| Source note | uspto-grants-2012_08 |