Acetic Acid → HCID 43349322, compound

HRID 883891Notes

Reaction equation

HRID 883891 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5](OS(C(F)(F)F)(=O)=O)=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1.[SH:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=1.O.C(O)(=O)C>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:19][C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)=[C:4]([N+:16]([O-:18])=[O:17])[CH:3]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 957384-Mercaptobenzoic acidHCID 713468894-Methyl-2-nitrophenyl trifluoromethanesulfonate

Product 1

HCID 43349322HCID 43349322, compoundYield 91.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from Example 9a (0.94 g, 3.31 mmol) was reacted with 4-mercapto-benzoic acid (0.51 g, 3.31 mmol) in aqueous ethanol at 80° C. under nitrogen. The reaction mixture was poured into water and acidified with glacial acetic acid. The solid product was collected by filtration, water washed and dried in vacuo to give the title compound (0.877 g, 91%) sufficiently pure for use as isolated.

Workup

  1. filtrationThe solid product was collected by filtration, water
  2. washwashed
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e9ad5238a0e243d882d3352996e1b5db
Source dataset
uspto-grants-2012_08
Patent number
US08236950B2

Reaction notes

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