5-Chloro-2-methyl-1,8-naphthyridine → HCID 67248596, compound

Participants

Reaction Steps

The product from Example 7d (557 mg, 3.12 mmol) was reacted with the product from Example 31b (1.032 mg, 3.12 mmol) for 18 h following the procedure from Example 7g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid (310 mg, 17%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 1.37 (s, 9 H) 2.76 (s, 3 H) 4.19 (d, J=6.25 Hz, 2 H) 6.29 (d, J=6.99 Hz, 1 H) 7.25 (s, 5 H) 7.31 (s, 1 H) 7.37 (d, J=3.31 Hz, 2 H) 7.44-7.56 (m, 1 H) 7.79 (d, J=8.82 Hz, 1 H) 8.42 (d, J=6.99 Hz, 1 H) 8.94 (d, J=8.46 Hz, 1 H) 11.05 (s, 1 H) 14.43 (s, 1 H); MS (ESI+) m/z 473 (M+H)+.

Provenance & Evidence