HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 4-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | 4-(4-Chloro-2-nitrophenoxy)benzoyl chloride | HCID 86615494 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-chloro-2-nitrophenoxy)-N-(2-methoxyethyl)benzamide | HCID 25931314 | — |
Reaction Steps
The compound from Example 34c (1.0 g, 3.2 mmol) in CH2Cl, was added to a mixture of 2-methoxyethanamine (722 mg, 9.61 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving the title compound as a yellow oil (1.1 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236950B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-0eb19f933332488b99aa77dee45322bd |
| Source note | uspto-grants-2012_08 |