5-Chloro-2-phenoxyaniline → (5-Chloro-2-phenoxy-phenyl)-[1,6]naphthyridin-5-yl-amine

Participants

Reaction Steps

The product from Example 36e (0.040 g, 0.24 mmol) was reacted with 5-chloro-2-phenoxy-phenylamine as (0.048 g, 0.24 mmol) for 48 h at 100° C. following the procedure from Example 7g giving the crude title compound which was purified by HPLC with TFA providing the product as a trifluoroacetic acid salt (0.046 g, 40%). 1H NMR (300 MHz, DMSO-d6) δ ppm: 6.96 (d, J=7.35 Hz, 2 H) 7.00-7.10 (m, 2 H) 7.22-7.39 (m, 4 H) 7.66 (dd, J=8.46, 4.41 Hz, 1 H) 7.91 (d, J=1.84 Hz, 1 H) 8.07 (d, J=6.25 Hz, 1 H) 8.76 (d, J=8.46 Hz, 1 H) 9.07 (d, J=3.31 Hz, 1 H); MS (ESI+) m/z 348.0 (M+H)+; (ESI−) m/z 346.1 (M−H)−.

Provenance & Evidence