HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-{4-[2-Amino-4-(3-methyl-benzyloxy)-phenylsulfanyl]-phenyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | m-Xylyl bromide | HCID 12099 | — |
| Reactant | N-[4-(2-Amino-4-hydroxy-phenylsulfanyl)-phenyl]-acetamide | HCID 67250701 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-{4-[2-Amino-4-(3-methyl-benzyloxy)-phenylsulfanyl]-phenyl}-acetamide | HCID 67250731 | 100% |
Reaction Steps
A mixture of the product from Example 38b (28 mg, 0.085 mmol), 3-methylbenzyl bromide (13 mg, 0.096 mmol) and potassium carbonate (13 mg, 0.09 mmol) in DMF (1 mL) was stirred at room temperature 15 hr. The next day, the reaction mixture was poured onto ice and the solid collected by filtration providing the tile compound (32 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236950B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-10d337f52be848c8ad9a72c4ad3cf713 |
| Source note | uspto-grants-2012_08 |