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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 883915Generated: October 26, 2026

Potassium Carbonate → N-{4-[2-Amino-4-(3-methyl-benzyloxy)-phenylsulfanyl]-phenyl}-acetamide

https://huagongshe.com/reaction/883915

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactantm-Xylyl bromideHCID 12099—
ReactantN-[4-(2-Amino-4-hydroxy-phenylsulfanyl)-phenyl]-acetamideHCID 67250701—
SolventDimethylformamideHCID 6228—
ProductN-{4-[2-Amino-4-(3-methyl-benzyloxy)-phenylsulfanyl]-phenyl}-acetamideHCID 67250731100%

Reaction Steps

A mixture of the product from Example 38b (28 mg, 0.085 mmol), 3-methylbenzyl bromide (13 mg, 0.096 mmol) and potassium carbonate (13 mg, 0.09 mmol) in DMF (1 mL) was stirred at room temperature 15 hr. The next day, the reaction mixture was poured onto ice and the solid collected by filtration providing the tile compound (32 mg, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08236950B2
Source datasetuspto-grants-2012_08
ORD IDord-10d337f52be848c8ad9a72c4ad3cf713
Source noteuspto-grants-2012_08