4-Chloro-3-nitrophenol → HCID 57469890, compound

HRID 883924Notes

Reaction equation

HRID 883924 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Cl.Cl[CH2:14][C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

3

Reactant 2

HCID 691274-Chloro-3-nitrophenolHCID 30838232-(Chloromethyl)quinoline hydrochloride

Product 1

HCID 57469890HCID 57469890, compound

Procedure

A solution of 4-chloro-3-nitro-phenol was reacted with 2-Chloromethyl-quinoline hydrochloride salt using the conditions described in Example 10C to provide 2-(4-Chloro-3-nitro-phenoxymethyl)-quinoline which was treated sequentially using the procedures from Examples 10D and 10E to provide the title product.

Sources & evidence

ORD record
ord-275af10bd6ed40e3ad438daa75ac0e28
Source dataset
uspto-grants-2012_08
Patent number
US08236950B2

Reaction notes

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