Hydrochloric Acid → HCID 42603178, compound

Participants

Reaction Steps

To a solution of 5b (90 mg, 0.184 mmol) in MeOH (3 ml) was added 4N HCl in 1,4-dioxane (0.5 ml) under ice cooling, and the mixture was stirred at room temperature for 2 h. A solution of NaHCO3 in H2O was poured into the reaction mixture under ice cooling, and the whole was extracted with AcOEt. The organic layer was washed with brine, dried over Na2SO4, and then concentrated. The residue was crystallized with Et2O to give 6b (84%). 6b: colorless powder; 1H-NMR (CD3OD) δ 1.07 (6H, d, J=6.8 Hz), 2.37 (6H, s), 2.79 (2H, t, J=5.4 Hz), 3.12 (1H, sep, J=5.4 Hz), 4.11 (2H, t, J=5.4 Hz), 6.46 (2H, d, J=8.8 Hz), 6.94 (2H, d, J=9.1 Hz), 6.95 (2H, d, J=8.8 Hz), 7.10 (2H, m), 7.16-7.25 (3H, m), 7.52 (2H, d, J=9.1 Hz). HRMS calcd for C28H33N2O3 [M+H]+: 445.2491. Found: 445.2510.

Provenance & Evidence