Hydrochloric Acid → HCID 68731668, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2a (195 mg, 0.573 mmol) in MeOH (6 ml) was added 2N NaOH (3 ml) and the mixture was stirred at 80° C. for 15 h. After cooling, 2 N HCl (3 ml) was added drop wise under ice cooling, and the whole was extracted with AcOEt, the organic layer was washed with brine, dried over Na2SO4, then concentrated. The residual solid was triturated with hexanes to give 3a (69%). 3a: colorless powder; 1H-NMR (CDCl3) δ 1.04 (3H, t, J=7.5 Hz), 2.83 (2H, t, J=7.5 Hz), 3.34 (3H, s), 4.93 (2H, s), 6.68 (1H, m), 6.73 (1H, d, J=7.6 Hz), 6.77 (2H, dd, J=2.5, 7.8 Hz), 7.01-7.07 (3H, m), 7.10-7.18 (3H, m).

Provenance & Evidence