Ethyl 3-[4-(4-nitrophenoxy)phenyl]propionate → HCID 68523825, compound

HRID 884101Notes

Reaction equation

HRID 884101 reaction equation
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:11][CH:10]=2)=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 68524232Ethyl 3-[4-(4-nitrophenoxy)phenyl]propionate

Product 1

HCID 68523825HCID 68523825, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

To a suspension of 5% palladium-carbon (0.50 g) in ethanol (50 mL) was added ethyl 3-[4-(4-nitrophenoxy)phenyl]propionate (5.00 g, 15.9 mmol), and the resulting solution was subjected to catalytic reduction at atmospheric pressure and at room temperature. Once the absorption of hydrogen had stopped, the catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure, to thereby yield 4.52 g of the title compound.

Workup

  1. customwas subjected to catalytic reduction at atmospheric pressure and at room temperature
  2. customOnce the absorption of hydrogen
  3. customthe catalyst was removed by filtration
  4. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ca8c73e303f3459ba544ce297ad6cd9b
Source dataset
uspto-grants-2012_08
Patent number
US08236826B2

Reaction notes

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