4-(Trifluoromethyl)benzaldehyde → HCID 68527465, compound

HRID 884114Notes

Reaction equation

HRID 884114 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[CH:11][C:10]=2[F:19])=[N:6][CH:7]=1.[F:20][C:21]([F:31])([F:30])[C:22]1[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=1>CO>[F:19][C:10]1[CH:11]=[C:12]([CH:17]=[CH:18][C:9]=1[O:8][C:5]1[CH:4]=[CH:3][C:2]([N:1]=[CH:26][C:25]2[CH:24]=[CH:23][C:22]([C:21]([F:20])([F:30])[F:31])=[CH:29][CH:28]=2)=[CH:7][N:6]=1)[C:13]([O:15][CH3:16])=[O:14]

Participants

4

Reactant 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 68524349HCID 68524349, compound

Product 1

HCID 68527465HCID 68527465, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 4-(5-aminopyridin-2-yloxy)-3-fluorobenzoate (2.0 g, 7.63 mmol) was dissolved in methanol (50 mL). To the resulting solution was added 4-trifluoromethylbenzaldehyde (1.04 mL, 7.63 mmol), and refluxed for 6 hours. The reaction solution was cooled to room temperature, and the resulting precipitated crystals were collected by suction filtration. The collected crystals were washed with methanol, to thereby yield 2.81 g of the title compound.

Workup

  1. temperaturerefluxed for 6 hours
  2. customthe resulting precipitated crystals
  3. filtrationwere collected by suction filtration
  4. washThe collected crystals were washed with methanol

Sources & evidence

ORD record
ord-c1ca26a1ce794b528c66447234e34809
Source dataset
uspto-grants-2012_08
Patent number
US08236826B2

Reaction notes

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