2-Fluoro-5-(trifluoromethyl)pyridine → HCID 58278646, compound

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Reaction Steps

The title compound was prepared following a procedure analogous to that described in Example 1 using (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-pyrrolidin-3-yl)-1,3-oxazinan-2-one and 2-fluoro-5-trifluoromethylpyridine at 150° C. for 20 min. LC-MS Method 1 tR=1.51 min, m/z=464(M+1); 1H NMR (CD3OD) 8.26(s, 1H), 8.00(d, 1H), 7.38(m, 4H), 7.29(m, 1H), 7.01(m, 1H), 4.74(m, 1H), 3.77(m, 2H), 3.58(q, 1H), 3.47(m, 1H), 2.83(m, 1H), 2.55(m, 2H), 2.18(s, 2H), 1.24(s, 3H), 0.94(s, 3H).

Provenance & Evidence