2-Chloro-4-(trifluoromethyl)pyrimidine → HCID 58278654, compound

HRID 884372Notes

Reaction equation

HRID 884372 reaction equation
[OH:1][C:2]([CH3:23])([CH3:22])[CH2:3][C@@:4]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]2[CH2:15][CH2:14][NH:13][CH2:12]2)[CH2:6][CH2:5]1.Cl[C:25]1[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=1>>[OH:1][C:2]([CH3:23])([CH3:22])[CH2:3][C@@:4]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]2[CH2:15][CH2:14][N:13]([C:25]3[N:30]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:28]=[CH:27][N:26]=3)[CH2:12]2)[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 27739122-Chloro-4-(trifluoromethyl)pyrimidineHCID 58278668HCID 58278668, compound

Product 1

HCID 58278654HCID 58278654, compound

Procedure

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-pyrrolidin-3-yl)-1,3-oxazinan-2-one and 2-chloro-4-(trifluoromethyl)pyrimidine following a procedure analogous to that described in

Sources & evidence

ORD record
ord-847b74769d254e70a79d8eb64c4c56e9
Source dataset
uspto-grants-2012_08
Patent number
US08242111B2

Reaction notes

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