Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 10885179, compound

Participants

Reaction Steps

A solution of 2.92 g of 204 (6.41 mmol) in 10 ml of anhydrous MeOH was added with 100 mg of PPTS (0.40 mmol, 6.2 mole %) and stirred at RT overnight. After checking completion of the reaction by means of TLC (EE/CH 1:7), the solution was concentrated, the remaining residue taken up in 25 ml of ethyl acetate and filtered over a small amount of silica gel. The filtrate was concentrated and further purified using silica gel column chromatography (EE/CH 1:7), thereby obtaining 2.98 g of 59 (6.34 mmol, 99%) as a colorless oil.

Provenance & Evidence