Water → HCID 23726640, compound

Participants

Reaction Conditions

Reaction Steps

2.67 g of 163 (5.73 mmol) was dissolved in 35 ml of anhydrous THF, cooled to 0° C. and added with 8.60 ml of TBAF solution (8.60 mmol, 1.5 eq., 1 M/THF). After reacting at RT overnight, 0.5 ml of water was added, followed by stirring for 30 min. Thereafter, the batch was filtered together with a small amount of MTBE over a small amount of silica gel and concentrated. Column chromatography over silica gel (EE/CH 1:3) afforded 1.28 g of alcohol 165 (5.63 mmol, 98%) as a colorless oil.

Provenance & Evidence