反应详情

4-Cyanopropiophenone (4.67 g, 29.3 mmol) was refluxed with 2N NaOH (90 mL, 180 mmol) and dioxane (90 mL) at 95° C. overnight. The mixture was diluted with water (150 mL), washed with ether (75 mL), acidified to pH 2 with concentrated HCl, and extracted with ether (3×75 mL). The organic phase was washed with saturated aqueous NaCl (3×75 mL), dried, and evaporated to give yellow solids (5.12 g, 98%).

1. washwashed with ether (75 mL)
2. extractionextracted with ether (3×75 mL)
3. washThe organic phase was washed with saturated aqueous NaCl (3×75 mL)
4. customdried
5. customevaporated