Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9879346 | HCID 9879346 | — |
Reaction Steps
A mixture of 5-chloro-2-nitrophenylamine (1.3 g, 7.0 mmol), 1-(2-pyridyl)-piperazine (3.5 g, 20 mmol), and K2CO3 (3.0 g, 22 mmol) in DMF (20 mL) was stirred at 110° C. for 48 h. The reaction mixture was cooled to room temperature and poured into water. The crude yellow solid was collected by vacuum filtration, air dried, and recrystallized from CHCl3 (0.36 g, 17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08242115B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-808c3039e51b42c892ffc4a2e6c5c525 |
|---|
| Source note | uspto-grants-2012_08 |
|---|
