2-(tert-butyl-dimethyl-silanyloxy)-5-Nitrobenzoic acid methyl ester → 5-Amino-2-(tert-butyl-dimethyl-silanyloxy)benzoic acid methyl ester

Beteiligte Stoffe

Reaktionsschritte

A solution of 2-(tert-butyl-dimethyl-silanyloxy)-5-Nitrobenzoic acid methyl ester (4.9 g, 16 mmol) in ethanol (100 mL) was treated with hydrogen gas (60 psi) for 48 h in the presence of palladium on carbon catalyst (0.31 g, 10% Pd). The catalyst was removed by filtration through CELITE®, and the filtrate was concentrated to a syrup and dried in vacuo to afford the intermediate 5-amino-2-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester as a dark brown solid (4.52 g, 99%).

Herkunft & Nachweise