Methanol → Methyl 4-bromo-2-methylbenzoate

Participants

Reaction Steps

To a round bottomed flask was added MeOH (25 mL) and commercially available 4-bromo-2-methyl benzoic acid (7.0 g, 32.8 mmol). Then 4N HCL/dioxanes (25 mL) was added to the insoluble mixture and stirred under reflux for 3 h. The reaction was concentrated. EtOAc and H2O were added to the slurry and partitioned. The EtOAc layer was washed with NaHCO3 (sat.) 3×, washed with brine and dried with Na2SO4 and concentrated to give methyl 4-bromo-2-methylbenzoate as a light brown oil (6.7 g, 89% yield).

Provenance & Evidence