Hydrochloric Acid → HCID 135900179, compound

Participants

Reaction Conditions

Reaction Steps

To a sealed pressure vessel was added (E)-tert-butyl 4-((4-(3-(4-hydroxy-3-methylphenyl)acryloyl)-3-methylphenoxy)methyl)piperidine-1-carboxylate (100 mg, 0.215 mmol), 4N HCl in dioxanes (2.0 mL), and urea (64 mg, 1.07 mmol). The pressure vessel was sealed and heated to 110° C. overnight. The reaction was then cooled to rt, concentrated via rotary evaporation and purified via preparatory HPLC (5-85% AmAc) to give 4-(4-hydroxy-3-methylphenyl)-6-(2-methyl-4-(piperidin-4-ylmethoxy)phenyl)pyrimidin-2(1H)-one (6.0 mg, 7% yield).

Provenance & Evidence